Riggs B L, Arnaud C D, Jowsey J, Goldsmith R S, Kelly P J
J Clin Invest. 1973 Jan;52(1):181-4. doi: 10.1172/JCI107162.
Two major species of serum immunoreactive parathyroid hormone (iPTH) were measured in 47 untreated patients with primary osteoporosis by using two highly specific radioimmunoassays. Mean iPTH was normal with one antiserum but was lower than normal (P < 0.001) with the other, iPTH values did not correlate with biochemical parameters or with the proportion of bone-resorbing surfaces in iliac crest bone biopsy specimens. These data suggest that the increased bone resorption is not due to increased parathyroid function in most osteoporotic patients. However, seven of our patients (15%) appear to represent a separate population because they had increased values with one or the other of the antisera.
通过两种高度特异性放射免疫分析法，对47例未经治疗的原发性骨质疏松症患者的血清免疫反应性甲状旁腺激素（iPTH）的两种主要类型进行了测定。使用一种抗血清时，iPTH平均值正常，但使用另一种抗血清时低于正常水平（P<0.001），iPTH值与生化参数或髂嵴骨活检标本中骨吸收表面的比例无关。这些数据表明，在大多数骨质疏松症患者中，骨吸收增加并非由于甲状旁腺功能增强。然而，我们的7例患者（15%）似乎代表了一个不同的群体，因为他们使用其中一种抗血清时数值升高。
