Joly R, Chapuy M C, Alexandre C, Meunier P J
Sem Hop. 1981;57(5-6):266-73.
In order to evaluate the relationship between apparently idiopathic osteoporosis and parathyroid hormone secretion, plasma immunoreactive parathyroid hormone (iPTH) was measured in 57 untreated osteoporotic patients using a carboxyl-terminal specific antiserum, and sections of undecalcified iliac bone biopsies from these subjects, who had been previously doubly labelled with tetracycline, were quantitatively analysed. Twenty-one patients (36%) exhibited histological signs of a high remodeling similar to that which is present in primary hyperparathyroidism, but their osteoplastic appositional rate values were lower. Among these 21 cases 8 had an increase of their iPTH levels. These data and those of the literature indicate that in a few cases high remodeling osteoporosis may be associated with parathyroid hypersecretion, but do not bring out the evidence that the increased circulating iPTH is the cause of osteoporosis. The authors draw from their results some practical consequences for the treatment of high remodeling osteoporosis.
为了评估明显特发性骨质疏松症与甲状旁腺激素分泌之间的关系，我们使用羧基末端特异性抗血清对57例未经治疗的骨质疏松症患者测定了血浆免疫反应性甲状旁腺激素（iPTH），并对这些之前用四环素进行双重标记的受试者的未脱钙髂骨活检切片进行了定量分析。21例患者（36%）表现出与原发性甲状旁腺功能亢进相似的高骨重塑组织学征象，但他们的骨形成附着率值较低。在这21例病例中，8例患者的iPTH水平升高。这些数据以及文献数据表明，在少数情况下，高骨重塑骨质疏松症可能与甲状旁腺分泌过多有关，但并未证实循环中iPTH升高是骨质疏松症的病因。作者从他们的结果中得出了一些对高骨重塑骨质疏松症治疗的实际影响。
