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阿尔茨海默病及实验性神经原纤维变性中的脑铝分布

Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration.

作者信息

Crapper D R, Krishnan S S, Dalton A J

出版信息

Science. 1973 May 4;180(4085):511-3. doi: 10.1126/science.180.4085.511.

DOI:10.1126/science.180.4085.511
PMID:4735595
Abstract

Neurofibrillary degeneration is an important pathological finding in senile and presenile dementia of the Alzheimer type. Experimentally, aluminum induces neurofibrillary degeneration in neurons of higher mammals. Aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease.

摘要

神经原纤维变性是阿尔茨海默型老年性和早老性痴呆的一项重要病理学发现。在实验中，铝可诱导高等哺乳动物神经元发生神经原纤维变性。在阿尔茨海默病患者大脑的某些区域已发现铝浓度接近实验中所使用的浓度。

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