Perl D P, Brody A R
Science. 1980 Apr 18;208(4441):297-9. doi: 10.1126/science.7367858.
The elemental content of neurons of the hippocampus was studied by a combination of scanning electron microscopy and x-ray spectrometry in autopsy-derived brain tissue from three cases of senile dementia (Alzheimer type) and three nondemented elderly controls. Foci of aluminum were detected within the nuclear region of a high percentage of neurons containing neurofibrillary tangles from the cases of senile dementia as well as the elderly controls. The adjacent normal-appearing neurons from both groups of patients were virtually free of detectable aluminum. These findings suggest that the association of aluminum to Alzheimer's disease extends to the neuronal level.
通过扫描电子显微镜和X射线光谱法相结合的方法，对3例老年性痴呆（阿尔茨海默型）患者和3名无痴呆的老年对照者尸检获得的脑组织中，海马神经元的元素含量进行了研究。在老年性痴呆患者以及老年对照者中，含有神经原纤维缠结的高比例神经元的核区域内检测到铝聚集灶。两组患者相邻的外观正常的神经元几乎未检测到铝。这些发现表明，铝与阿尔茨海默病的关联延伸至神经元水平。
