多烯抗生素鲁森霉素与红细胞膜及模型系统中胆固醇的相互作用。I. 荧光和分光光度研究。
The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. I. A fluorometric and spectrophotometric study.
作者信息
Strom R, Crifò C, Bozzi A
出版信息
Biophys J. 1973 Jun;13(6):568-80. doi: 10.1016/S0006-3495(73)86007-2.
Abstract
The increase of fluorescence emission of lucensomycin occurring upon interaction with cholesterol, either as colloidal suspension or included in phospholipid micelles or in erythrocyte membranes, was described. Colloidal cholesterol differed from that contained in membranes by the kinetic behavior of its interaction with lucensomycin, the reaction being very slow in the former case, very fast in the latter one. Variations of optical density also occurred, though neither the kinetics nor the titration curves were superimposable on those obtained fluorometrically. The stoichiometry was, however, the same.
摘要
本文描述了鲁西诺霉素与胆固醇相互作用时荧光发射的增加情况，胆固醇以胶体悬浮液形式存在，或包含在磷脂微团或红细胞膜中。胶体胆固醇与膜中所含胆固醇在与鲁西诺霉素相互作用的动力学行为上有所不同，在前一种情况下反应非常缓慢，在后一种情况下反应非常迅速。同时也出现了光密度的变化，尽管动力学和滴定曲线都与荧光法测得的结果无法叠加。然而，化学计量比是相同的。
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