多烯抗生素鲁森霉素与红细胞膜及模型系统中胆固醇的相互作用。II. 红细胞膜中的协同效应。
The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. II. Cooperative effects in erythrocyte membranes.
作者信息
Strom R, Crifò C, Santoro A S
出版信息
Biophys J. 1973 Jun;13(6):581-93. doi: 10.1016/S0006-3495(73)86008-4.
Abstract
Fluorometric titration curves of erythrocyte membranes with increasing lucensomycin have a sigmoid shape. This behavior, which was not present when colloidal cholesterol suspensions were used, is, however, not peculiar to the membrane structure, being also present in cholesterol-containing phospholipid micelles. Addition of acetic acid induced or increased sigmoidicity. This behavior can either be due to a true cooperativity in binding or to different fluorescence yields of the various lucensomycin-membrane complexes. The latter hypothesis appears to be slightly favored.
摘要
随着鲁西诺霉素浓度增加，红细胞膜的荧光滴定曲线呈S形。然而，当使用胶体胆固醇悬浮液时不存在这种行为，它并非膜结构所特有，含胆固醇的磷脂微团中也存在这种行为。添加乙酸会诱导或增强S形特征。这种行为可能是由于结合过程中存在真正的协同作用，或者是由于各种鲁西诺霉素-膜复合物具有不同的荧光产率。后一种假设似乎略占上风。
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引用本文的文献
1
The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. I. A fluorometric and spectrophotometric study.
Biophys J. 1973 Jun;13(6):568-80. doi: 10.1016/S0006-3495(73)86007-2.
2
The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. III. Characterization of spectral parameters.
Biophys J. 1976 Nov;16(11):1297-314. doi: 10.1016/S0006-3495(76)85775-X.
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The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. I. A fluorometric and spectrophotometric study.
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