多烯抗生素鲁森霉素与红细胞膜及模型系统中胆固醇的相互作用。II. 红细胞膜中的协同效应。
The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. II. Cooperative effects in erythrocyte membranes.
作者信息
Strom R, Crifò C, Santoro A S
出版信息
Biophys J. 1973 Jun;13(6):581-93. doi: 10.1016/S0006-3495(73)86008-4.
Abstract
Fluorometric titration curves of erythrocyte membranes with increasing lucensomycin have a sigmoid shape. This behavior, which was not present when colloidal cholesterol suspensions were used, is, however, not peculiar to the membrane structure, being also present in cholesterol-containing phospholipid micelles. Addition of acetic acid induced or increased sigmoidicity. This behavior can either be due to a true cooperativity in binding or to different fluorescence yields of the various lucensomycin-membrane complexes. The latter hypothesis appears to be slightly favored.
摘要
随着鲁西诺霉素浓度增加，红细胞膜的荧光滴定曲线呈S形。然而，当使用胶体胆固醇悬浮液时不存在这种行为，它并非膜结构所特有，含胆固醇的磷脂微团中也存在这种行为。添加乙酸会诱导或增强S形特征。这种行为可能是由于结合过程中存在真正的协同作用，或者是由于各种鲁西诺霉素-膜复合物具有不同的荧光产率。后一种假设似乎略占上风。
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The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. II. Cooperative effects in erythrocyte membranes.多烯抗生素鲁森霉素与红细胞膜及模型系统中胆固醇的相互作用。II. 红细胞膜中的协同效应。
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引用本文的文献
1
The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. I. A fluorometric and spectrophotometric study.多烯抗生素鲁森霉素与红细胞膜及模型系统中胆固醇的相互作用。I. 荧光和分光光度研究。
Biophys J. 1973 Jun;13(6):568-80. doi: 10.1016/S0006-3495(73)86007-2.
2
The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. III. Characterization of spectral parameters.多烯抗生素鲁森霉素与红细胞膜及模型系统中胆固醇的相互作用。III. 光谱参数的表征
Biophys J. 1976 Nov;16(11):1297-314. doi: 10.1016/S0006-3495(76)85775-X.
本文引用的文献
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Peptide-protein interaction as studied by gel filtration.通过凝胶过滤研究的肽-蛋白质相互作用。
Biochemistry. 1966 Feb;5(2):673-83. doi: 10.1021/bi00866a038.
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The ion permeability induced in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B.多烯抗生素制霉菌素和两性霉素B在薄脂质膜中诱导产生的离子通透性。
J Gen Physiol. 1970 Jul;56(1):100-24. doi: 10.1085/jgp.56.1.100.
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Polyene macrolide antibiotic amphotericin B. Crystal structure of the N-iodoacetyl derivative.
J Am Chem Soc. 1971 Sep 8;93(18):4560-4. doi: 10.1021/ja00747a037.
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The planar organization of lecithin-cholesterol bilayers.卵磷脂 - 胆固醇双层膜的平面结构
J Biol Chem. 1972 Jun 10;247(11):3694-7.
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The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems. I. A fluorometric and spectrophotometric study.多烯抗生素鲁森霉素与红细胞膜及模型系统中胆固醇的相互作用。I. 荧光和分光光度研究。
Biophys J. 1973 Jun;13(6):568-80. doi: 10.1016/S0006-3495(73)86007-2.
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