Sokolova V E, Liubartseva L A
Vopr Med Khim. 1979 Jul-Aug;25(4):379-82.
Content of free ammonia and glutamine amide nitrogen was increased but content of protein amide nitrogen was decreased in brain tissue after bilateral nephrectomy of rats causing development an experimental uremia; an increased synthesis of urea and activation of arginase were observed in liver tissue. Flavonoids robinine and hyperine decreased the content of free ammonia, increased the content of glutamine amide nitrogen as well as of protein amide nitrogen in rat brain; robinine decreased slightly the urea synthesis and the arginase activity in liver slices of the nephrectomized rats.
大鼠双侧肾切除导致实验性尿毒症发展后，脑组织中游离氨和谷氨酰胺酰胺氮含量增加，但蛋白质酰胺氮含量降低；在肝组织中观察到尿素合成增加和精氨酸酶活性增强。黄酮类化合物刺槐苷和金丝桃苷降低了大鼠脑中游离氨的含量，增加了谷氨酰胺酰胺氮以及蛋白质酰胺氮的含量；刺槐苷略微降低了肾切除大鼠肝切片中的尿素合成和精氨酸酶活性。
