Pessenhofer H, Kerschhaggl P, Schwaberger G
Wien Med Wochenschr. 1979 Jun 30;129(13):361-4.
On the basis of two examples of projects being realized in the department of physiology in Graz the use of engineering methods in physiological research is demonstrated. The first example presents a survey of the use of system-theoretical methods for the investigation of overall regulation of circulation under working conditions. Using two test-signals (impulse input, random input) for experimental identification, the impulse response of heart-rate to changes in work load was obtained. The impulse responses of the volunteers were then characterized by a set of three parameters, allowing statistical evaluation, classification for diagnostic means and verification of hypotheses. The second example deals with an investigation of the signal structure of ultrasound-CW-Doppler-systems. Basing on the general Doppler-principle, which is already in use in angiology it was tried to quantify the determinants of the audio-signal, describing it by statistical functions and by experiments on simple models (tube-models). The goal of the experiments is a quantitative assessment of volume-flow and an enhancement of information about the scattering medium (rheological properties of blood).
基于格拉茨大学生理学系正在实施的两个项目实例，展示了工程方法在生理学研究中的应用。第一个实例介绍了运用系统理论方法研究工作状态下循环系统的整体调节。通过使用两个测试信号（脉冲输入、随机输入）进行实验识别，获得了心率对工作负荷变化的脉冲响应。然后，用一组三个参数对志愿者的脉冲响应进行表征，以便进行统计评估、用于诊断手段的分类以及假设验证。第二个实例涉及对超声连续波多普勒系统信号结构的研究。基于血管学中已使用的一般多普勒原理，试图对音频信号的决定因素进行量化，通过统计函数和在简单模型（管道模型）上进行实验来描述该信号。实验的目标是对体积流量进行定量评估，并增强有关散射介质（血液的流变特性）的信息。
