绵羊、猪和大鼠对[14C]苯酚的代谢

Metabolism of [14C]phenol by sheep, pig and rat.

Kao J, Bridges J W, Faulkner J K

Xenobiotica. 1979 Mar;9(3):141-7. doi: 10.3109/00498257909038714.

Abstract

Following an oral dose of [14C]phenol (12.5 or 25 mg/kg) to sheep, pig and rat, urinary elimination of radioactivity was rapid, 80-90% dose being excreted in the first 8 h. 2. In anaesthetized, ureter-cannulated rats, 70-80% of an intraduodenal dose was eliminated in 2 h; 2% dose was excreted as phenol conjugates in the urine within 10 min. 3. The major urinary metabolites from phenol (25 mg/kg) were phenylglucuronide and phenylsulphate. In the sheep, pig and rat, the glucuronide accounted for 49%, 83% and 42% respectively, of the total urinary metabolites and sulphate accounted for 32%, 1% and 55%. Conjugates of quinol were minor urinary metabolites (less than 7%) in all three species. 4. In sheep some 12% of the urinary metabolites was conjugated with phosphate; this metabolite was not found in rat or pig.

摘要

给绵羊、猪和大鼠口服[14C]苯酚（12.5或25毫克/千克）后，放射性物质经尿液快速排出，80 - 90%的剂量在最初8小时内排出。2. 在麻醉且输尿管插管的大鼠中，十二指肠内给药剂量的70 - 80%在2小时内排出；2%的剂量在10分钟内以苯酚结合物的形式经尿液排出。3. 苯酚（25毫克/千克）的主要尿液代谢产物为苯基葡萄糖醛酸苷和苯基硫酸盐。在绵羊、猪和大鼠中，葡萄糖醛酸苷分别占总尿液代谢产物的49%、83%和42%，硫酸盐分别占32%、1%和55%。喹啉结合物在所有三个物种中均为次要尿液代谢产物（少于7%）。4. 在绵羊中，约12%的尿液代谢产物与磷酸盐结合；在大鼠或猪中未发现这种代谢产物。