Ito N, Nagasaki H, Aoe H, Sugihara S, Miyata Y
J Natl Cancer Inst. 1975 Mar;54(3):801-5.
The effects of prolonged oral administration of the alpha-, beta-, and gamma-isomers of benzene hexachloride (BHC) on rat liver were examined histologically. Well-differentiated hepatocellular carcinomas were observed in the liver of rats fed a basal diet containing 1,500 or 1,000 parts per million (ppm) of alpha-BHC for 72 weeks. Many typical nodular hyperplasias developed in all groups given 1,500 or 1,000 ppm alpha-BHC. In non-neoplastic areas, slight oval cell infiltration and bile duct proliferation were seen. No neoplastic changes or other abnormal findings, such as oval cell infiltration, fatty changes, fibrosis, or bile duct proliferation of the liver, were observed in groups receiving 500 ppm alpha-, beta-, gamma-, or gamma-BHC.
通过组织学检查了长期口服六六六（BHC）的α-、β-和γ-异构体对大鼠肝脏的影响。在喂食含百万分之一千五百或百万分之一千α-六六六基础日粮72周的大鼠肝脏中观察到高分化肝细胞癌。给予百万分之一千五百或百万分之一千α-六六六的所有组中均出现许多典型的结节性增生。在非肿瘤区域，可见轻度卵圆细胞浸润和胆管增生。在接受百万分之五百α-、β-、γ-或δ-六六六的组中，未观察到肝脏的肿瘤性变化或其他异常发现，如卵圆细胞浸润、脂肪变性、纤维化或胆管增生。
