Santi P A, Duvall A J
Acta Otolaryngol. 1979;88(1-2):1-12. doi: 10.3109/00016487909137133.
Chinchillas were given either a single injection of the diuretic bumetanide (18 mg/kg body weight) or saline-sodium hydroxide and sacrificed at 10 min, 1 hr and 24 hr after the injection. Slight stria edema was present at 10 min, marked edema at 1 hr and no edema 24 h after bumetanide. The edema began in the first cochlear turn at 10 min and spread to the second turn by 1 hr. Along with edema, marginal cell bulging, potential capillary constriction and the formation of marginal cell membranous structures occurred after bumetanide treatment.
给栗鼠单次注射利尿剂布美他尼（18毫克/千克体重）或生理盐水-氢氧化钠，在注射后10分钟、1小时和24小时处死。注射布美他尼后10分钟出现轻微的条纹水肿，1小时出现明显水肿，24小时无水肿。水肿在10分钟时始于耳蜗第一圈，1小时时蔓延至第二圈。布美他尼治疗后，除水肿外，还出现了边缘细胞肿胀、潜在的毛细血管收缩以及边缘细胞膜性结构的形成。
