Ala-Houhala I, Uotila A, Pasternack A, Krohn K
Acta Med Scand. 1979;205(7):583-6. doi: 10.1111/j.0954-6820.1979.tb06108.x.
Cellular immune reactivity was studied in 78 patients with various forms of renal disease by skin testing with four recall antigens and a lymphocyte transformation test with tuberculin PPD and leucoagglutinin. Patients with S-creatine greater than or equal to 230 micromol/l as well as those with chronic pyelonephritis who had S-creatinine values below 230 micromol/l had significantly lower skin reactions than the controls to streptokinase-streptodornase, parotitis and PPD. Glomerulonephritic patients with S-creatinine values below 230 micromol/l had normal skin reactivity. Lymphocyte transformation tests showed decreased reactivity only in patients with S-creatinine level greater than or equal to 230 micromol/l. The results suggest an association of chronic pyelonephritis with a defective efferent, nonspecific arm of cellular immunity.
通过对四种回忆抗原进行皮肤试验以及用结核菌素PPD和白细胞凝集素进行淋巴细胞转化试验，研究了78例各种形式肾病患者的细胞免疫反应性。血清肌酐大于或等于230微摩尔/升的患者以及血清肌酐值低于230微摩尔/升的慢性肾盂肾炎患者，对链激酶-链道酶、腮腺炎和PPD的皮肤反应明显低于对照组。血清肌酐值低于230微摩尔/升的肾小球肾炎患者皮肤反应正常。淋巴细胞转化试验显示，仅血清肌酐水平大于或等于230微摩尔/升的患者反应性降低。结果表明慢性肾盂肾炎与细胞免疫的传出性非特异性分支缺陷有关。
