接受苯乙双胍治疗的糖尿病患者维生素B12吸收不良：与二甲双胍的比较。
Malabsorption of vitamin B12 in diabetic patients treated with phenformin: a comparison with metformin.
作者信息
Tomkin G H
出版信息
Br Med J. 1973 Sep 29;3(5882):673-5. doi: 10.1136/bmj.3.5882.673.
Abstract
An investigation into B(12) absorption in diabetic patients on long-term phenformin therapy was undertaken and the results were compared to a similar investigation previously reported in diabetics on long-term metformin. Forty-six per cent of patients were found to have B(12) malabsorption as shown by abnormal results of Schilling tests.The mechanism of B(12) malabsorption is unknown but it is suggested that all patients on long-term phenformin therapy should, like the patients on metformin, have annual serum B(12) estimations until the results of a longer follow-up series are known.
摘要
对长期服用苯乙双胍治疗的糖尿病患者的维生素B12吸收情况进行了一项调查，并将结果与之前报道的长期服用二甲双胍的糖尿病患者的类似调查结果进行了比较。通过希林试验结果异常发现，46%的患者存在维生素B12吸收不良。维生素B12吸收不良的机制尚不清楚，但建议所有长期服用苯乙双胍治疗的患者，应像服用二甲双胍的患者一样，每年进行血清维生素B12测定，直到有更长随访系列的结果出来。
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Malabsorption of vitamin B12 in diabetic patients treated with phenformin: a comparison with metformin.接受苯乙双胍治疗的糖尿病患者维生素B12吸收不良：与二甲双胍的比较。
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