Stoddard C J, Waterfall W E, Brown B H, Duthie H L
Gut. 1973 Aug;14(8):657-64. doi: 10.1136/gut.14.8.657.
The effects of varying the extent of vagotomy on the myoelectrical and motor activity of the stomach have been successfully studied in 21 patients undergoing either truncal, selective, or highly selective vagotomy for the treatment of chronic duodenal ulceration. The mean percentage time that regular antral myoelectrical activity was recorded preoperatively was 95.8% +/- 1.0 and this was decreased following highly selective vagotomy (74.0% +/- 6.6), selective vagotomy (37.8% +/- 12.4), and truncal vagotomy (30.2% +/- 10.4). The mean amplitude of the pacesetter potential was less following truncal (0.86 mV +/- 0.05), selective (1.32 mV +/- 0.09), and highly selective vagotomy (1.67 +/- 0.09) than in preoperative studies (2.21 mV +/- 0.12). Following truncal and selective vagotomies the triphasic waveform of the pacesetter potential changed to a sinusoidal shape. No significant change in the mean preoperative frequency of the myoelectrical activity (3.03 cpm +/- 0.08) occurred after vagotomy. Thus the changes in the electrical activity of the stomach are related to the extent of the vagal denervation. Intravenous administration of insulin did not alter these patterns except after highly selective vagotomy when the amplitude of the electrical waves, the incidence of action potentials, and percentage motor activity were increased.
在21例因慢性十二指肠溃疡接受全胃迷走神经切断术、选择性迷走神经切断术或高选择性迷走神经切断术治疗的患者中，已成功研究了改变迷走神经切断范围对胃肌电活动和运动活性的影响。术前记录到的正常胃窦肌电活动的平均时间百分比为95.8%±1.0，在高选择性迷走神经切断术后（74.0%±6.6）、选择性迷走神经切断术后（37.8%±12.4）和全胃迷走神经切断术后（30.2%±10.4）均有所降低。与术前研究（2.21 mV±0.12）相比，全胃迷走神经切断术（0.86 mV±0.05）、选择性迷走神经切断术（1.32 mV±0.09）和高选择性迷走神经切断术后（1.67±0.09）的起搏电位平均幅度较小。在全胃迷走神经切断术和选择性迷走神经切断术后，起搏电位的三相波形变为正弦波形。迷走神经切断术后，肌电活动的术前平均频率（3.03次/分钟±0.08）无显著变化。因此，胃电活动的变化与迷走神经去神经支配的范围有关。静脉注射胰岛素并未改变这些模式，但在高选择性迷走神经切断术后，电波幅度、动作电位发生率和运动活性百分比增加。
