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The substrate analog, bromopyruvate, as a bridging agent for the active site of 2-keto-3-deoxy-6-phosphogluconic aldolase. Chemical evidence for a carboxylate adjacent to the Schiff's base-forming lysine.

作者信息

Meloche H P

出版信息

J Biol Chem. 1973 Oct 25;248(20):6945-51.

PMID:4743508
Abstract
摘要

相似文献

1
The substrate analog, bromopyruvate, as a bridging agent for the active site of 2-keto-3-deoxy-6-phosphogluconic aldolase. Chemical evidence for a carboxylate adjacent to the Schiff's base-forming lysine.
J Biol Chem. 1973 Oct 25;248(20):6945-51.
2
Reaction of the substrate analog bromopyruvate with two active-site conformers of 2-keto-3-deoxy-6 phosphogluconic aldolase.
Biochemistry. 1970 Dec 22;9(26):5050-5. doi: 10.1021/bi00828a002.
3
The conformation of catalytically functional Schiff's bases: the pyruvate--lysine ketimine of 2-keto-3-deoxygluconate-6-phosphate aldolase of Pseudomonas putida.
Arch Biochem Biophys. 1980 Sep;203(2):702-6. doi: 10.1016/0003-9861(80)90229-5.
4
The substrate analog, bromopyruvate, as both a substrate and alkylating agent for 2-keto-3-deoxy-6-phosphogluconic aldolase. Kinetic and stereochemical studies.底物类似物溴丙酮酸作为2-酮-3-脱氧-6-磷酸葡萄糖醛酸醛缩酶的底物和烷基化剂。动力学和立体化学研究。
J Biol Chem. 1972 Jul 10;247(13):4186-91.
5
The mechanism of 2-keto-3-deoxy-6-phosphogluconate aldolase. 3. Nature of the inactivation by fluorodinitrobenzene.
J Biol Chem. 1971 Jun 25;246(12):4028-35.
6
Structure of 2-keto-3-deoxy-6-phosphogluconate aldolase. 3. Sequence of a hexadecapeptide containing the azomethine-forming lysine residue.2-酮-3-脱氧-6-磷酸葡萄糖酸醛缩酶的结构。3. 包含形成甲亚胺赖氨酸残基的十六肽序列。
J Biol Chem. 1971 Apr 10;246(7):2084-90.
7
Structure of 2-keto-3-deoxy-6-phosphogluconate aldolase. II. Chemical evidence for a three-subunit molecule.2-酮-3-脱氧-6-磷酸葡萄糖酸醛缩酶的结构。II. 关于三聚体分子的化学证据。
J Biol Chem. 1971 Apr 10;246(7):2075-83.
8
Bromopyruvate inactivation of 2-keto-3-deoxy-6-phosphogalactonate aldolase of Pseudomonas saccharophila. Kinetics and stereochemistry.
Biochemistry. 1975 Aug 12;14(16):3682-7. doi: 10.1021/bi00687a026.
9
THE MECHANISM OF 2-KETO-3-DEOXY-6-PHOSPHOGLUCONIC ALDOLASE.
J Biol Chem. 1964 Oct;239:3511-4.
10
Aldolase catalysis: single base-mediated proton activation.醛缩酶催化作用：单碱基介导的质子活化
Science. 1973 Jul 27;181(4097):350-2. doi: 10.1126/science.181.4097.350.

引用本文的文献

1
Selective modification of rabbit muscle pyruvate kinase by 5-chloro-4-oxopentanoic acid.5-氯-4-氧代戊酸对兔肌肉丙酮酸激酶的选择性修饰
Biochem J. 1976 Nov;159(2):201-11. doi: 10.1042/bj1590201.
2
Identification of cysteine as the reactive group in pyruvate kinase alkylated by 5-chloro-4-oxopentanoic acid.鉴定半胱氨酸为被5-氯-4-氧代戊酸烷基化的丙酮酸激酶中的反应基团。
Biochem J. 1976 Nov;159(2):213-9. doi: 10.1042/bj1590213.