Juel R
Am J Clin Pathol. 1979 Aug;72(2 Suppl):306-19.
In 1978 the College of American Pathologists introduced a Therapeutic Drug Monitoring Interlaborabory Survey Program. Each participant recieved six vials of lyophilized human serum on two occasions, approximately 13 weeks apart. The specimens contained various combinations of 12 drugs in subtherapeutic, therapeutic, and toxic concentrations. The drugs included in the specimens were phenytoin, phenobarbital, primidone, ethosuximide, carbamazepine, digoxin, procainamide, N-acetylprocainamide, quinidine, theophylline, lithium, and gentamicin. The weighed-in quantity of each drug was used as the target value for that drug. The specimens were analyzed by a variety of analytic methods. Statistics were calculated for all results regardless of the analytic method used and for each individual method. This report presents the data from the Program.
1978年，美国病理学家学会推出了一项治疗药物监测实验室间调查计划。每位参与者分两次收到六瓶冻干人血清，两次间隔约13周。这些标本含有12种药物的不同组合，浓度分别为亚治疗浓度、治疗浓度和中毒浓度。标本中包含的药物有苯妥英、苯巴比妥、扑米酮、乙琥胺、卡马西平、地高辛、普鲁卡因胺、N-乙酰普鲁卡因胺、奎尼丁、茶碱、锂和庆大霉素。每种药物的称取量用作该药物的目标值。标本通过多种分析方法进行分析。无论使用何种分析方法，都会对所有结果以及每种单独的方法进行统计计算。本报告展示了该计划的数据。
