（1-脱氨基，4-缬氨酸）-8-D-精氨酸加压素（DVDAVP）的固相合成，DVDAVP是一种具有持久作用的高效特异性抗利尿药。 - Suppr

Suppr

超能文献

Solid phase synthesis of (1-deamino,4-valine)-8-D-arginine-vasopressin (DVDAVP), a highly potent and specific antidiuretic agent possessing protracted effects.

作者信息

Manning M, Balaspiri L, Acosta M, Sawyer W H

出版信息

J Med Chem. 1973 Sep;16(9):975-8. doi: 10.1021/jm00267a004.

DOI:10.1021/jm00267a004

PMID:4745513

Abstract

摘要

相似文献

Solid phase synthesis of (1-deamino,4-valine)-8-D-arginine-vasopressin (DVDAVP), a highly potent and specific antidiuretic agent possessing protracted effects.（1-脱氨基，4-缬氨酸）-8-D-精氨酸加压素（DVDAVP）的固相合成，DVDAVP是一种具有持久作用的高效特异性抗利尿药。

J Med Chem. 1973 Sep;16(9):975-8. doi: 10.1021/jm00267a004.

Solid-phase synthesis and some pharmacological properties of deamino-4-threonine analogs of the vasopressins and vasotocin and (deamino)arginine-vasotocin.

J Med Chem. 1973 Jul;16(7):836-9. doi: 10.1021/jm00265a020.

Solid-phase synthesis and some pharmacological properties of 4-threonine analogs of vasopressins and vasotocin and of arginine-vasopressin and arginine-vasotocin.血管加压素和催产素以及精氨酸血管加压素和精氨酸催产素的4-苏氨酸类似物的固相合成及其一些药理性质。

J Med Chem. 1973 May;16(5):463-6. doi: 10.1021/jm00263a009.

Synthesis and some pharmacological properties of 8-L-homoarginine-vasopressin and of 1-deamino-8-L-homoarginine-vasopressin.8-L-高精氨酸加压素和1-去氨基-8-L-高精氨酸加压素的合成及某些药理性质

J Med Chem. 1974 Jul;17(7):781-3. doi: 10.1021/jm00253a035.

Solid phase synthesis and some hormonal activities of 1-deamino-4-L-valine-8-D-homolysine-and 1-deamino-4-L-valine-8-D-homoarginine-vasopressin.1-去氨基-4-L-缬氨酸-8-D-高赖氨酸和1-去氨基-4-L-缬氨酸-8-D-高精氨酸加压素的固相合成及其某些激素活性

Int J Pept Protein Res. 1977;10(3):240-4. doi: 10.1111/j.1399-3011.1977.tb01740.x.

Synthesis and some of the pharmacological properties of (4-leucine)-8-lysine-vasopressin and (1-deamino,4-leucine)-8-lysine-vasopressin.（4-亮氨酸）-8-赖氨酸加压素和（1-去氨基，4-亮氨酸）-8-赖氨酸加压素的合成及其某些药理特性

J Med Chem. 1973 Jul;16(7):843-7. doi: 10.1021/jm00265a022.

Synthesis and some pharmacological properties of deamino(4-threonine,8-D-arginine)vasopressin and deamino(8-D-arginine)vasopressin, highly potent and specific antidiuretic peptides, and (8-D-arginine)vasopressin and deamino-arginine-vasopressin.去氨基（4-苏氨酸，8-D-精氨酸）加压素、去氨基（8-D-精氨酸）加压素、高效特异性抗利尿肽、（8-D-精氨酸）加压素及去氨基精氨酸加压素的合成与某些药理特性

J Med Chem. 1976 Jun;19(6):842-5. doi: 10.1021/jm00228a023.

Role of the disulfide bridge and the C-terminal tripeptide in the antidiuretic action of vasopressin in man and the rat.二硫键和C末端三肽在血管加压素对人和大鼠抗利尿作用中的作用。

Kidney Int. 1975 Nov;8(5):292-302. doi: 10.1038/ki.1975.116.

2-O-alkyltyrosine derivatives of 1-deamino-arginine-vasopressin: highly specific and potent antidiuretic agonists.1-脱氨基-精氨酸加压素的2-O-烷基酪氨酸衍生物：高特异性强效抗利尿激动剂

J Med Chem. 1989 Jan;32(1):244-7. doi: 10.1021/jm00121a043.

Pharmacology of oxytocin-(1-6)-hexapeptide amide, vasopressin-(1-6)-hexapeptide amide and their deamino analogues.

Eur J Pharmacol. 1973 Nov;24(2):179-82. doi: 10.1016/0014-2999(73)90069-1.

引用本文的文献

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin.受自然启发的二聚化作为一种调节神经肽药理学的策略，以加压素和催产素为例进行说明。

Chem Sci. 2021 Feb 4;12(11):4057-4062. doi: 10.1039/d0sc05501h.

Trends in peptide drug discovery.肽类药物研发趋势。

Nat Rev Drug Discov. 2021 Apr;20(4):309-325. doi: 10.1038/s41573-020-00135-8. Epub 2021 Feb 3.

Revisiting oxytocin through the medium of isonitriles.重新审视异腈媒介下的催产素。

J Am Chem Soc. 2012 Aug 15;134(32):13244-7. doi: 10.1021/ja3063452. Epub 2012 Aug 2.

Antidiuretic hormone restores the endolymphatic longitudinal K+ gradient in the Brattleboro rat cochlea.

Pflugers Arch. 1994 Mar;426(5):446-52. doi: 10.1007/BF00388309.

Cyclic and linear vasopressin V1 and V1/V2 antagonists containing arginine in the 4-position.

Experientia. 1991 Jan 15;47(1):83-6. doi: 10.1007/BF02041261.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验