Cyclic and linear vasopressin V1 and V1/V2 antagonists containing arginine in the 4-position.
作者信息
Sawyer W H, Lammek B, Misicka A, Kruszynski M, Kolodzieczyk A, Manning M
机构信息
Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032.
出版信息
Experientia. 1991 Jan 15;47(1):83-6. doi: 10.1007/BF02041261.
PMID:1999249
Abstract
Substitution of arginine for glutamine in the 4-position of a vasopressin V1 antagonist has been reported to turn it into an agonist. We resynthesized this 4-arginine analog and synthesized additional cyclic and linear vasopressin antagonists containing a 4-arginine. The presence of a 4-arginine in the resynthesized and new analogs had relatively minor effects on their antivasopressin V1 and V2 antagonistic potencies.
摘要
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