Papageorgiou A, Wiglesworth F W, Schiff D, Stern L
Can Med Assoc J. 1973 Oct 20;109(8):717-20.
A case of Reye's syndrome in a newborn infant, believed to be the first recorded in the perinatal period, is reported. The clinical, biochemical and histological findings are those previously recognized in older infants. The intractable acidosis, hypoglycemia and extreme degree of lactic acidosis reflect an advanced degree of hepatic involvement, probably initiated in utero, with resultant impairment of glycogenolysis and intermediary metabolism.
据报道，一名新生儿患瑞氏综合征，这被认为是围产期有记录的首例病例。临床、生化及组织学检查结果与以往在较大婴儿中所认识到的相符。难治性酸中毒、低血糖及严重的乳酸酸中毒反映出肝脏受累程度严重，可能始于子宫内，导致糖原分解及中间代谢受损。
