Hilliard G D, Massey F M, O'Toole R V
Am J Obstet Gynecol. 1979 Sep 15;135(2):185-8. doi: 10.1016/0002-9378(79)90340-5.
Vulvar intraepithelial neoplasms may be occurring more frequently among younger age groups. Six patients with carcinoma in situ or severe vulvar dysplasia are reported, as well as one patient with microinvasive carcinoma, all under the age of 30 years. The vulvar lesions were noted to be mostly multicentric. They were associated with other intraepithelial neoplasias of the cervix or vagina in four of the six cases. The lesions were most often mistaken for condyloma acuminatum. Histologic changes were primarily Bowen's disease or Bowenoid dysplasia.
外阴上皮内瘤变在较年轻年龄组中可能更频繁地发生。报告了6例原位癌或重度外阴发育异常患者，以及1例微浸润癌患者，均未满30岁。外阴病变大多为多中心性。6例中有4例与宫颈或阴道的其他上皮内瘤变相关。这些病变最常被误诊为尖锐湿疣。组织学改变主要为鲍温病或鲍温样发育异常。
