Wilson E A, Finn A E, Rayburn W, Jawad M J
Am J Obstet Gynecol. 1979 Sep 15;135(2):215-8. doi: 10.1016/0002-9378(79)90346-6.
Corticosteroid-binding globulin (CBG) is produced by the liver in small concentrations and binds steroids with high affinity. Its concentration in the blood is sensitive to endogenous or exogenous estrogens in a dose-response manner and serves as a biological assay for estrogens. CBG concentrations were measured in sera collected from maternal and umbilical vein blood during labor and delivery and at elective cesarean section and correlated with endogenous estradiol and estriol concentrations. CBG and estradiol concentrations of maternal blood were significantly exceeded those of maternal serum. A highly significant increase in cord blood estriol concentration was found following vaginal delivery compared to elective cesarean section, indicating an increase in adrenal activity due to the stress of labor. CBG levels correlated directly with maternal estradiol but not estriol cencentrations. Cord blood CBG concentration varied little despite a wide range of estrogen concentrations. The physiologic significance of CBG concentrations in maternal and fetal blood is discussed.
皮质类固醇结合球蛋白（CBG）由肝脏少量产生，能与类固醇高亲和力结合。其在血液中的浓度对内源或外源性雌激素呈剂量反应敏感，并可作为雌激素的生物学检测指标。在分娩及选择性剖宫产时，测定了母体和脐静脉血血清中的CBG浓度，并与内源性雌二醇和雌三醇浓度进行关联。母体血液中的CBG和雌二醇浓度显著超过母体血清。与选择性剖宫产相比，经阴道分娩后脐血雌三醇浓度显著升高，表明分娩应激导致肾上腺活性增加。CBG水平与母体雌二醇直接相关，但与雌三醇浓度无关。尽管雌激素浓度范围广泛，但脐血CBG浓度变化不大。本文讨论了母体和胎儿血液中CBG浓度的生理意义。
