美西螈肾脏近端小管中的双离子电位。
Biionic potentials in the proximal tubule of Necturus kidney.
作者信息
Anagnostopoulos T
出版信息
J Physiol. 1973 Sep;233(2):375-94. doi: 10.1113/jphysiol.1973.sp010313.
Abstract
- Biionic potentials were studied in the proximal tubule of the doubly perfused Necturus kidney and subsequently analysed by means of an equivalent electrical circuit.2. Luminal membrane resistance was found to be at least 3 times greater than peritubular membrane resistance.3. Potassium contribution to peritubular membrane conductance amounts to at least 75%. Replacement of chloride in peritubular circulation by benzene sulphonate or acetyl glycinate hyperpolarized peritubular membrane.4. The peritubular membrane is more permeable to choline than to sodium. Indirect evidence suggests that the opposite may apply at the luminal border.5. The shunt pathway discriminates poorly, if at all, between sodium, potassium and choline, in short term experiments.6. Chloride permeability across the shunt pathway is about three times as great as combined cationic permeabilities.
摘要
研究了双灌注美西螈肾脏近端小管中的生物离子电位，随后通过等效电路进行分析。
发现管腔膜电阻至少比肾小管周围膜电阻大3倍。
钾对肾小管周围膜电导的贡献至少达75%。用苯磺酸盐或乙酰甘氨酸替代肾小管周围循环中的氯会使肾小管周围膜超极化。
肾小管周围膜对胆碱的通透性比对钠的通透性更高。间接证据表明，在管腔边界可能情况相反。
在短期实验中，分流途径对钠、钾和胆碱的区分能力很差，甚至根本无法区分。
氯通过分流途径的通透性约为阳离子总通透性的三倍。
相似文献
1
Biionic potentials in the proximal tubule of Necturus kidney.美西螈肾脏近端小管中的双离子电位。
J Physiol. 1973 Sep;233(2):375-94. doi: 10.1113/jphysiol.1973.sp010313.
2
Organic anion permeation at the proximal tubule of necturus: an electrophysiological study of the peritubular membrane.
Pflugers Arch. 1979 Sep;381(3):231-9. doi: 10.1007/BF00583254.
3
Electrophysiological study of the antiluminal membrane in the proximal tubule of Necturus: effect of inorganic anions and SCN-.美西螈近端小管抗腔面膜的电生理研究：无机阴离子和硫氰酸盐的作用
J Physiol. 1977 May;267(1):89-111. doi: 10.1113/jphysiol.1977.sp011803.
4
Further studies on ion permeation in proximal tubule of necturus kidney.美西螈肾近端小管离子渗透的进一步研究。
Am J Physiol. 1978 Aug;235(2):F89-95. doi: 10.1152/ajprenal.1978.235.2.F89.
5
Potassium permeability of luminal and peritubular membranes in the proximal tubule of bullfrog kidneys.牛蛙肾脏近端小管管腔膜和肾小管周围膜的钾通透性。
Jpn J Physiol. 1990;40(5):613-34. doi: 10.2170/jjphysiol.40.613.
6
The effect of a disulfonic acid stilbene on proximal cell membrane potential in Necturus kidney.二磺酸芪对美西螈肾近端细胞膜电位的影响。
Biochim Biophys Acta. 1978 Dec 4;514(1):137-44. doi: 10.1016/0005-2736(78)90083-4.
7
pH-dependent electrical properties and buffer permeability of the Necturus renal proximal tubule cell.美西螈肾近端小管细胞的pH依赖性电学性质和缓冲液通透性
J Membr Biol. 1987;100(2):165-82. doi: 10.1007/BF02209148.
8
Measurements of electrical potential differences on single nephrons of the perfused Necturus kidney.对灌注的美西螈肾脏单个肾单位的电位差测量。
J Gen Physiol. 1961 Mar;44(4):659-78. doi: 10.1085/jgp.44.4.659.
9
Anion permeation in the proximal tubule of Necturus kidney: the shunt pathway.美西螈肾脏近端小管中的阴离子渗透：分流途径。
J Membr Biol. 1975 Dec 4;24(3-4):365-80. doi: 10.1007/BF01868632.
10
Intracellular ion activities in Necturus proximal tubule.美西螈近端小管中的细胞内离子活性。
Fed Proc. 1979 Dec;38(13):2729-32.
引用本文的文献
1
Chloride transport in the renal proximal tubule.肾近端小管中的氯离子转运。
Pflugers Arch. 2004 Sep;448(6):561-70. doi: 10.1007/s00424-004-1309-y. Epub 2004 Jul 16.
2
Conductive properties of the proximal tubule in Necturus kidney.泥螈肾脏近端小管的传导特性
J Gen Physiol. 1980 May;75(5):553-87. doi: 10.1085/jgp.75.5.553.
3
The effects of barium on the electrical properties of the basolateral membrane in proximal tubule.钡对近端小管基底外侧膜电特性的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Dec;318(2):135-41. doi: 10.1007/BF00508838.
4
Chloride movement across the basolateral membrane of proximal tubule cells.氯离子跨近端小管细胞基底外侧膜的转运。
J Membr Biol. 1981 Jan 30;58(1):35-42. doi: 10.1007/BF01871032.
5
The electrical profile of the distal tubule in Triturus kidney.蝾螈肾脏远曲小管的电活动情况。
Pflugers Arch. 1982 Nov 1;395(2):138-44. doi: 10.1007/BF00584727.
6
Electrical properties of chloride transport across the necturus proximal tubule.美西螈近端肾小管氯离子转运的电特性
J Membr Biol. 1982;65(3):185-96. doi: 10.1007/BF01869962.
7
Electrical resistance of cell membranes in Necturus kidney.美西螈肾脏细胞膜的电阻
Pflugers Arch. 1974;346(4):327-39. doi: 10.1007/BF00596188.
8
Cell and luminal activities of chloride, potassium, sodium and protons in the late distal tubule of Necturus kidney.美西螈肾脏远曲小管晚期氯离子、钾离子、钠离子和质子的细胞及管腔活动
J Physiol. 1987 Dec;393:73-89. doi: 10.1113/jphysiol.1987.sp016811.
9
Mechanisms of 1,25(OH)2D3-induced rapid changes of membrane potential in proximal tubule: role of Ca2+-dependent K+ channels.1,25-二羟维生素D3诱导近端小管膜电位快速变化的机制：钙依赖性钾通道的作用
J Membr Biol. 1986;90(2):137-43. doi: 10.1007/BF01869931.
10
Barium- or quinine-induced depolarization activates K+, Na+ and cationic conductances in frog proximal tubular cells.钡或奎宁诱导的去极化激活蛙近端肾小管细胞中的钾离子、钠离子和阳离子电导。
J Physiol. 1992 Mar;448:525-37. doi: 10.1113/jphysiol.1992.sp019055.
本文引用的文献
1
Single proximal tubules of Necturus kidney. V. Unidirectional sodium movement.美西螈肾脏的单个近端小管。V. 钠的单向移动。
Am J Physiol. 1963 Mar;204:372-6. doi: 10.1152/ajplegacy.1963.204.3.372.
2
Single proximal tubules of Necturus kidney. VI. Nature of potassium transport.美西螈肾脏的单个近端小管。VI. 钾转运的本质。
Am J Physiol. 1963 Mar;204:377-80. doi: 10.1152/ajplegacy.1963.204.3.377.
3
Ionic permeability and electrical potential differences in Necturus kidney cells.美西螈肾细胞中的离子通透性和电位差
J Gen Physiol. 1961 Mar;44(4):689-712. doi: 10.1085/jgp.44.4.689.
4
Measurements of electrical potential differences on single nephrons of the perfused Necturus kidney.对灌注的美西螈肾脏单个肾单位的电位差测量。
J Gen Physiol. 1961 Mar;44(4):659-78. doi: 10.1085/jgp.44.4.659.
5
Effect of ionic substitutions on distal potential differences in rat kidney.离子置换对大鼠肾脏远端电位差的影响。
Am J Physiol. 1966 Sep;211(3):560-8. doi: 10.1152/ajplegacy.1966.211.3.560.
6
Studies on the electrical potential profile across rabbit ileum. Effects of sugars and amino acids on transmural and transmucosal electrical potential differences.兔回肠跨膜电位分布的研究。糖和氨基酸对跨壁和跨黏膜电位差的影响。
J Gen Physiol. 1971 Jun;57(6):639-63. doi: 10.1085/jgp.57.6.639.
7
Necturus kidney: its response to effects of isotonic volume expansion.泥螈肾脏：其对等渗性容量扩张效应的反应。
Am J Physiol. 1970 Jan;218(1):205-13. doi: 10.1152/ajplegacy.1970.218.1.205.
8
Electrophysiology of proximal and distal tubules in the autoperfused dog kidney.自体灌注犬肾近端和远端小管的电生理学
Am J Physiol. 1971 Oct;221(4):1084-96. doi: 10.1152/ajplegacy.1971.221.4.1084.
9
The effect of D-glucose on the electrical potential profile across the proximal tubule of newt kidney.D-葡萄糖对蝾螈肾脏近端小管跨膜电位分布的影响。
Biochim Biophys Acta. 1972 Sep 1;282(1):214-25. doi: 10.1016/0005-2736(72)90327-6.
10
Ionic conductances of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential differences.兔回肠细胞外分流途径的离子电导。分流对跨壁钠转运和电位差的影响。
J Gen Physiol. 1972 Mar;59(3):318-46. doi: 10.1085/jgp.59.3.318.
Zotero 插件