各种抗心磷脂抗体与完整线粒体的反应性。

Reactivity of various anticardiolipin antibodies with intact mitochondria.

作者信息

Aho K, Rostedt I, Saris N E

出版信息

Clin Exp Immunol. 1973 Aug;14(4):573-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553805/

Abstract

Human syphilitic sera and BFP sera react with cardiolipin of intact rat liver and bovine heart mitochondria as evidenced by the absorption of the Wassermann antibody into mitochondria and by complement-fixation with diluted mitochondrial suspension. In contrast, rabbit antisera induced by immunization with floccules consisting of human syphilitic serum and VDRL antigen did not bind to mitochondria to any appreciable extent. The difference was not related to the 19S/7S class of the antibody. It was not related to any difference between man and rabbit either since sera of rabbits with experimental syphilis resembled human syphilitic sera more than rabbit sera induced by immunization with floccules.

摘要

人类梅毒血清和牛胎儿苍白密螺旋体血清与完整大鼠肝脏和牛心脏线粒体的心磷脂发生反应，瓦色曼抗体在线粒体内的吸收以及与稀释线粒体悬液的补体结合证明了这一点。相比之下，用人梅毒血清和性病研究实验室（VDRL）抗原组成的絮状物免疫诱导的兔抗血清在任何明显程度上都不与线粒体结合。这种差异与抗体的19S/7S类别无关。它也与人兔之间的任何差异无关，因为患有实验性梅毒的兔血清比用絮状物免疫诱导的兔血清更类似于人类梅毒血清。

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本文引用的文献

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SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS.原发性胆汁性肝硬化诊断中的血清学检测

Lancet. 1965 Apr 17;1(7390):827-31. doi: 10.1016/s0140-6736(65)91372-3.

2

Studies on the production of Wassermann reagin.关于瓦色曼反应素产生的研究。

J Immunol. 1962 May;88:591-4.

3

Studies of syphilitic antibodies. I. Anti-lipoidal antibodies in various stages of syphilis.梅毒抗体研究。一、梅毒各阶段的抗类脂抗体。

Br J Vener Dis. 1967 Dec;43(4):259-63. doi: 10.1136/sti.43.4.259.

4

Immunochemical studies of phospholipids. 3. Production of antibody to cardiolipin.磷脂的免疫化学研究。3. 抗心磷脂抗体的产生。

Biochim Biophys Acta. 1967 Oct 2;144(2):409-14.

5

Mitochondrial antibodies in primary biliary cirrhosis. 3. Characterization of the inner-membrane complement fixing antigen.原发性胆汁性肝硬化中的线粒体抗体。3. 内膜补体结合抗原的特性

Clin Exp Immunol. 1969 May;4(5):511-25.

6

Studies of syphilitic antibodies. IV. Evidence of reactant partner common for C-reactive protein and certain anti-lipoidal antibodies.梅毒抗体研究。IV. C反应蛋白与某些抗脂质抗体共同反应成分的证据。

Br J Vener Dis. 1969 Mar;45(1):13-8. doi: 10.1136/sti.45.1.13.

7

Mitochondrial and other tissue autoantibodies in patients with biological false positive reactions for syphilis.梅毒生物学假阳性反应患者的线粒体及其他组织自身抗体

Clin Exp Immunol. 1970 Jun;6(6):871-84.

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J Lipid Res. 1967 May;8(3):170-80.

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