Akiyama T, Serrino P
Am J Physiol. 1979 Sep;237(3):H392-4. doi: 10.1152/ajpheart.1979.237.3.H392.
Use of a motion-compensated micropipette holder, which senses cardiac motion and lifts and lowers the micropipette and supporting apparatus in synchrony with the heart beat, allows for stable recording of transmembrane action potentials from subepicardial cells of an in vivo beating heart in an open-chest dog without significantly impairing cardiac hemodynamics. This technique may be used to study the effects of ischemia, hypertrophy, or pharmacologic agents on the cellular electrophysiological parameters of subepicardial ventricular cells of an in vivo beating heart.
使用一种运动补偿微量移液器支架，该支架可感知心脏运动，并与心跳同步升降微量移液器及支撑装置，从而能够在不显著影响心脏血流动力学的情况下，稳定记录开胸犬体内跳动心脏的心外膜下细胞的跨膜动作电位。该技术可用于研究缺血、肥大或药物制剂对体内跳动心脏的心外膜下心室细胞的细胞电生理参数的影响。
