吞噬作用对人中性粒细胞中氨基酸掺入蛋白质的抑制作用。
Inhibition of amino acid incorporation into protein of human neutrophils by phagocytosis.
作者信息
DeChatelet L R, McCall C E, McPhail L C
出版信息
Infect Immun. 1973 Nov;8(5):791-5. doi: 10.1128/iai.8.5.791-795.1973.
Abstract
The incorporation of uniformly labeled (14)C-amino acids into total protein of human polymorphonuclear leukocytes is inhibited when the cells are challenged with heat-killed Escherichia coli or latex particles. Parallel studies of amino acid incorporation and glucose oxidation indicate that the inhibition is dependent upon ingestion of the particles. It is suggested that the process of phagocytosis might inhibit the transport of amino acids into the cell either by competing for available energy or by internalizing specific transport sites.
摘要
当人多形核白细胞受到热灭活的大肠杆菌或乳胶颗粒刺激时，均匀标记的（14）C -氨基酸掺入人多形核白细胞总蛋白的过程受到抑制。对氨基酸掺入和葡萄糖氧化的平行研究表明，这种抑制取决于颗粒的摄取。有人提出，吞噬作用过程可能通过竞争可用能量或通过内化特定转运位点来抑制氨基酸向细胞内的转运。
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本文引用的文献
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TRANSPORT OF NEUTRAL AND DIBASIC AMINO ACIDS BY HUMAN LEUKOCYTES: ABSENCE OF DEFECT IN CYSTINURIA.人白细胞对中性和二碱基氨基酸的转运：胱氨酸尿症不存在缺陷。
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