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Aberration of porphyrin metabolism in iron-deficient anaemic rats.缺铁性贫血大鼠卟啉代谢的异常
Biochem J. 1973 Jul;134(3):821-3. doi: 10.1042/bj1340821.
2
Porphyrin biosynthesis in the erythrocytes of patients with sideropenic anaemias.缺铁性贫血患者红细胞中的卟啉生物合成
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Erythrocyte delta-aminolaevulinic acid dehydratase, urinary porphyrins and porphyrin precursors in iron deficiency anaemia.
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Characterization of protoporphyrin as the physiological regulatory of delta-aminolevulinate dehydratase in Neurospora crassa.原卟啉作为粗糙脉孢菌中δ-氨基乙酰丙酸脱水酶的生理调节剂的特性研究。
Biochim Biophys Acta. 1980 Apr 30;607(2):331-8. doi: 10.1016/0005-2787(80)90085-4.
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Porphyrin synthesis and metabolism in iron deficiency anaemia. II. In vitro studies.
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Urinary excretion of porphyrins is increased in patients with HIV-1 infection.
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Aminolaevulinate dehydratase porphyria in infancy. A clinical and biochemical study.婴儿期氨基乙酰丙酸脱水酶卟啉症。一项临床与生化研究。
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缺铁性贫血大鼠卟啉代谢的异常

Aberration of porphyrin metabolism in iron-deficient anaemic rats.

作者信息

Sharma D C

出版信息

Biochem J. 1973 Jul;134(3):821-3. doi: 10.1042/bj1340821.

DOI:10.1042/bj1340821
PMID:4749280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1177881/
Abstract

Iron-deficient rats excreted greater amounts of 5-aminolaevulinate in urine but the output of porphobilinogen was decreased considerably. In addition, activity of the enzyme 5-aminolaevulinate dehydratase was diminished in bone marrow and liver. The results suggest that in iron deficiency a defect occurs in porphyrin synthesis at the level of porphobilinogen formation.

摘要

缺铁大鼠尿中排泄的5-氨基酮戊酸量更多，但卟啉原的排出量则显著减少。此外，骨髓和肝脏中5-氨基酮戊酸脱水酶的活性降低。结果表明，在缺铁状态下，卟啉合成在卟啉原形成水平上出现缺陷。