缺铁性贫血大鼠卟啉代谢的异常
Aberration of porphyrin metabolism in iron-deficient anaemic rats.
作者信息
Sharma D C
出版信息
Biochem J. 1973 Jul;134(3):821-3. doi: 10.1042/bj1340821.
Abstract
Iron-deficient rats excreted greater amounts of 5-aminolaevulinate in urine but the output of porphobilinogen was decreased considerably. In addition, activity of the enzyme 5-aminolaevulinate dehydratase was diminished in bone marrow and liver. The results suggest that in iron deficiency a defect occurs in porphyrin synthesis at the level of porphobilinogen formation.
摘要
缺铁大鼠尿中排泄的5-氨基酮戊酸量更多，但卟啉原的排出量则显著减少。此外，骨髓和肝脏中5-氨基酮戊酸脱水酶的活性降低。结果表明，在缺铁状态下，卟啉合成在卟啉原形成水平上出现缺陷。
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