通过对人红细胞δ-氨基-γ-酮戊酸脱水酶的反馈抑制来控制血红素合成。
Control of haem synthesis by feedback inhibition on human-erythrocyte delta-aminolaevulate dehydratase.
作者信息
Calissano P, Bonsignore D, Cartasegna C
出版信息
Biochem J. 1966 Nov;101(2):550-2. doi: 10.1042/bj1010550.
Abstract
The action of haem, haemoglobin and other haemoproteins on crude and purified delta-aminolaevulate dehydratase of human erythrocyte is described. The results show a feedback inhibition by haem of porphyrin synthesis at the level of erythrocyte delta-aminolaevulate dehydratase. Some kinetic characteristics of this inhibition are described.
摘要
本文描述了血红素、血红蛋白及其他血红素蛋白对人红细胞粗提和纯化的δ-氨基-γ-酮戊酸脱水酶的作用。结果表明，在红细胞δ-氨基-γ-酮戊酸脱水酶水平上，血红素对卟啉合成具有反馈抑制作用。本文还描述了这种抑制作用的一些动力学特征。
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Control of haem synthesis by feedback inhibition on human-erythrocyte delta-aminolaevulate dehydratase.通过对人红细胞δ-氨基-γ-酮戊酸脱水酶的反馈抑制来控制血红素合成。
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引用本文的文献
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
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3
THE EFFECT OF HEMIN ON THE SYNTHESIS OF GLOBIN.氯高铁血红素对珠蛋白合成的影响。
Biochem Biophys Res Commun. 1965 Jan 18;18:236-42. doi: 10.1016/0006-291x(65)90746-1.
4
delta-aminolaevulate dehydratase from Rhodopseudomonas spheroides.来自球形红假单胞菌的δ-氨基乙酰丙酸脱水酶
Biochem J. 1963 Jun;87(3):462-72. doi: 10.1042/bj0870462.
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The purification and properties of ALA dehydratase from human erythrocytes.人红细胞中δ-氨基-γ-酮戊酸脱水酶的纯化及性质
Ital J Biochem. 1966 Jan-Feb;15(1):18-29.
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7
[On the mechanism of erythrocyte ALA dehydratase inhibition by lead].[关于铅对红细胞δ-氨基-γ-酮戊酸脱水酶的抑制机制]
Med Lav. 1965 Nov;56(11):727-31.
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