Quintanilla A, Kessler R H
J Clin Invest. 1973 Dec;52(12):3143-53. doi: 10.1172/JCI107514.
Sodium salicylate was administered to anesthetized dogs in doses sufficient to produce concentrations in plasma comparable to those common in human salicylate toxicity. Salicylate administration increased the rates of excretion of water, sodium, and chloride in the urine. Salicylate administration also increased the rate of excretion of potassium so that its clearance often exceeded that of creatinine. This enhancement of potassium excretion was dissociated from the alkalosis that accompanies salicyate toxicity. Administration of 5% CO(2) in inspired gas did not attenuate the excretion of potassium; injection of salicylate into one renal artery caused a unilateral kaliuresis. Phosphate excretion increased progressively after administration of salicylate. On several occasions the clearance of phosphate equalled that of creatinine. Salicylate reduced renal tubular glucose reabsorption. When salicylate was injected into a renal artery, a glycosuria occurred ipsilaterally at filtered loads of glucose far below the reabsorptive capacity of the dog kidney. Salicylate administration also was associated with early elevation of glucose, phosphate, and potassium concentration in plasma. Salicylate administration reduced the content of adenosine triphosphate in the renal medulla. Salicylate was concentrated within the medulla between 1.5 and 3 times that of the cortex, a gradient equal to that for chloride.
将水杨酸钠以足以在血浆中产生与人类水杨酸盐中毒常见浓度相当的浓度的剂量给予麻醉犬。给予水杨酸盐增加了尿中水、钠和氯的排泄率。给予水杨酸盐还增加了钾的排泄率，以至于其清除率常常超过肌酐的清除率。钾排泄的这种增强与水杨酸盐中毒伴随的碱中毒无关。在吸入气体中给予5%二氧化碳并没有减弱钾的排泄；将水杨酸盐注入一条肾动脉会引起单侧尿钾增多。给予水杨酸盐后磷酸盐排泄逐渐增加。有几次磷酸盐的清除率与肌酐的清除率相当。水杨酸盐减少肾小管对葡萄糖的重吸收。当将水杨酸盐注入肾动脉时，在远低于犬肾重吸收能力的葡萄糖滤过量时，同侧会出现糖尿。给予水杨酸盐还与血浆中葡萄糖、磷酸盐和钾浓度的早期升高有关。给予水杨酸盐降低了肾髓质中三磷酸腺苷的含量。水杨酸盐在髓质中的浓度是皮质的1.5至3倍，这一梯度与氯化物的梯度相当。
