Gray D A, Langrieger N, Reschmaier J, Simon E
Br J Pharmacol. 1984 Jun;82(2):329-38. doi: 10.1111/j.1476-5381.1984.tb10767.x.
The acute effects of intravenously administered lysine-acetylsalicylic acid (ASA) on renal function in the Pekin duck have been studied with special reference to possible interactions with the antidiuretic hormone, arginine vasotocin (AVT), in the control of renal water and solute output. ASA produces an immediate increase in urine flow rate which is dose-related in the range 25 to 100 mg kg-1 and is associated with a slight reduction in urine osmolality, but an overall increase in renal osmolal excretion affecting Na+, Cl- and K+ to approximately equal extents. The effects, which are similar in both saltwater and freshwater adapted ducks infused with hyposmotic saline or glucose solution, can also be produced by similar doses of sodium salicylate (SA). The mechanism of action is probably not related to inhibition of prostaglandin synthetases. There is no change in the glomerular filtration rate or peripheral blood pressure following the ASA injection. There is no change in the circulating level of AVT; however, preliminary studies do not exclude the possibility of a partial antagonism of salicylate to AVT at the renal level.
研究了静脉注射赖氨酸 - 乙酰水杨酸（ASA）对北京鸭肾功能的急性影响，并特别参考了其在控制肾脏水和溶质排出方面与抗利尿激素精氨酸血管加压素（AVT）可能的相互作用。ASA可使尿流率立即增加，在25至100 mg kg-1范围内呈剂量相关，且伴有尿渗透压略有降低，但肾脏渗透压排泄总体增加，对Na+、Cl-和K+的影响程度大致相等。在输注低渗盐水或葡萄糖溶液的适应咸水和淡水的鸭子中，相同剂量的水杨酸钠（SA）也可产生类似效果。其作用机制可能与抑制前列腺素合成酶无关。注射ASA后，肾小球滤过率和外周血压无变化。AVT的循环水平无变化；然而，初步研究并未排除水杨酸盐在肾脏水平对AVT产生部分拮抗作用的可能性。
