Desmet G, Nemitz B, Boitieux J L, Agha B E, Muir J F
Ann Biol Clin (Paris). 1979;37(2):83-8.
The authors propose a simple and reliable method for determination of alphaxalone [3 alpha-hydroxy(5 alpha)pregnane 11,20 dione] in serum and urine, during long-duration anaesthesia using Althesin, mixture of alphaxalone and alphadolone acetate [21 acetoxy, 3 alpha-hydroxy(5 alpha)pregnane 11,20 dione]. If assays of alphadolone appear difficult and without any precision, because of numerous interferences, the determination of alphaxalone in serum and urine seems interesting for pharmacokinetic and metabolic investigation. We confirm the quick rate of disappearance of alphaxalone from blood, associated with a very active metabolism in the liver. The results show that it exists a relation between the concentration of alphaxalone in blood and the value of anaesthesia judged on clinical and electrical criteria. We cannot however conclude that Althesin presents a cumulative effect, because we used important amounts of anaesthetic agent.
作者提出了一种简单可靠的方法，用于在使用阿尔泰辛（alphaxalone和醋酸阿法多龙[21-乙酰氧基，3α-羟基（5α）孕烷-11,20-二酮]的混合物）进行长时间麻醉期间测定血清和尿液中的阿法沙龙[3α-羟基（5α）孕烷-11,20-二酮]。如果由于众多干扰因素导致对阿法多龙的测定似乎困难且缺乏任何精度，那么血清和尿液中阿法沙龙的测定对于药代动力学和代谢研究似乎很有意义。我们证实了阿法沙龙从血液中快速消失的速率，这与肝脏中非常活跃的代谢有关。结果表明，血液中阿法沙龙的浓度与根据临床和电标准判断的麻醉值之间存在关系。然而，我们不能得出阿尔泰辛具有累积效应的结论，因为我们使用了大量的麻醉剂。
