Righter H F, Showalter D H, Teske R H
Am J Vet Res. 1979 May;40(5):713-5.
Sulfadimethoxine was administered (IV) to suckling pigs (1 to 2 weeks old) and to growing pigs (11 to 12 weeks old) at a dosage of 55 mg/kg of body weight (single dose). Blood samples were collected over a 48-hour period, and the animals euthanatized were used for measurements of plasma and tissue concentrations of the drug. The blood data were described, using a one-compartment pharmacokinetic model. The blood concentration curves for the two groups of pigs had a consistent depletion pattern with greater than therapeutic concentrations (50 micrograms/ml) of the drug persisting through 12 hours after the drug was given. Sulfonamide blood concentrations were 4 and 11 times that of the method sensitivities in the older (growing) and younger (suckling) pigs, respectively, at 48 hours after treatment. In four of the five pharmacokinetic variables studied, a significantly higher (P less than 0.01) degree of efficiency was observed in the ability of the older pigs to eliminate the drug than in the younger pigs.
给1至2周龄的哺乳仔猪和11至12周龄的生长猪静脉注射磺胺二甲氧嘧啶，剂量为55毫克/千克体重（单剂量）。在48小时内采集血样，并对安乐死的动物进行药物血浆和组织浓度测量。使用单室药代动力学模型描述血液数据。两组猪的血药浓度曲线呈现出一致的下降模式，给药后12小时内药物浓度持续高于治疗浓度（50微克/毫升）。治疗后48小时，生长猪和哺乳仔猪的磺胺类药物血药浓度分别是方法灵敏度的4倍和11倍。在所研究的五个药代动力学变量中的四个中，观察到生长猪消除药物的能力效率显著高于哺乳仔猪（P小于0.01）。
