Drudge J H, Lyons E T, Tolliver S C, Kubis J E
Am J Vet Res. 1979 Jun;40(6):758-61.
The efficacy of oxibendazole given at dose level of 10 mg/kg of body weight was determined by 10 critical tests in foals and by 2 clinical trials in 20 foals (16 treated, 4 nontreated), with special interest in the drug activity against Parascaris equorum. The drug was uniformly efficacious (100%) against P equorum in the 10 critical-test foals, each having between 22 and 236 ascarids. Posttreatment reductions of ascarid egg counts in fecal samples were also 100% in suckling foals treated with oxibendazole given as a drench. Ascarid eggs did not reappear in fecal samples until the 8th week after foals were treated. A paste formulation of oxibendazole at 10 mg/kg also eliminated ascarid eggs from feces of 12 suckling foals. Strongyle EPG were markedly reduced by oxibendazole in the 10 critical-test foals and in 16 treated sucklings in the clinical trials. Egg and larval count data on foals in both the critical tests and the clinical trials also indicated oxibendazole was active against Strongyloides westeri. Untoward effects of treatment with oxibendazole were not observed.
通过对驹进行10次关键试验以及对20匹驹（16匹接受治疗，4匹未治疗）进行2次临床试验，确定了按10毫克/千克体重剂量给予奥昔苯达唑的疗效，特别关注该药物对马副蛔虫的活性。在10匹关键试验驹中，每匹驹体内有22至236条蛔虫，该药物对马副蛔虫的疗效均为100%。用奥昔苯达唑灌服治疗的哺乳驹粪便样本中蛔虫卵计数的治疗后减少率也为100%。在驹接受治疗后的第8周之前，粪便样本中未再次出现蛔虫卵。按10毫克/千克体重的奥昔苯达唑膏剂配方也清除了12匹哺乳驹粪便中的蛔虫卵。在10次关键试验驹以及临床试验中的16匹接受治疗的哺乳驹中，奥昔苯达唑显著降低了圆线虫每克粪便虫卵数（EPG）。关键试验和临床试验中驹的虫卵和幼虫计数数据也表明奥昔苯达唑对马类圆线虫有活性。未观察到奥昔苯达唑治疗的不良反应。
