Manning P J
Am J Vet Res. 1979 Jun;40(6):820-8.
Primary hypothyroidism with marked hyperlipoproteinemia and modest to severe atherosclerosis was described in a family of Beagles. The disease was familial and probably hereditary, but the mode of inheritance was unknown. Signs of the disease occurred as early as 1.5 years of age and as late as 5 years of age. The onset of the disease was heralded by reduced concentrations of serum thyroxine, increased binding capacity of thyroxine-binding globulin, and reduced response to injected thyroxine-stimulating hormone. Thereafter, serum lipids, particularly serum cholesterol, increased markedly even though the dogs consumed a diet low in fats and cholesterol. Thyroxine administration resulted in a precipitous decline in serum cholesterol concentrations. Microscopic changes in the thyroid glands included neoplastic transformation, adenomatous hyperplasia, lymphocytic thyroiditis, and atrophy. Moderate to severe atherosclerosis occurred mainly in the coronary and renal arteries. Atherosclerotic arteries were stenotic but patent, and there was no evidence of prior occlusion or thrombosis.
在一个比格犬家族中描述了原发性甲状腺功能减退伴明显的高脂蛋白血症和中度至重度动脉粥样硬化。该疾病具有家族性且可能具有遗传性，但遗传方式未知。疾病迹象最早出现在1.5岁，最晚出现在5岁。疾病发作的先兆是血清甲状腺素浓度降低、甲状腺素结合球蛋白结合能力增加以及对注射的促甲状腺激素反应降低。此后，即使这些犬食用低脂肪和低胆固醇饮食，血清脂质，尤其是血清胆固醇仍显著增加。给予甲状腺素导致血清胆固醇浓度急剧下降。甲状腺的微观变化包括肿瘤转化、腺瘤样增生、淋巴细胞性甲状腺炎和萎缩。中度至重度动脉粥样硬化主要发生在冠状动脉和肾动脉。动脉粥样硬化的动脉狭窄但通畅，没有先前闭塞或血栓形成的证据。
