Patterson J S, Rusley M S, Zachary J F
J Am Vet Med Assoc. 1985 Mar 1;186(5):499-503.
A 6-year-old, obese, spayed female Doberman pinscher dog was presented for clinical examination with a 1-day history of repeated seizures and a long-term history of periodic bouts of ataxia, circling, and head tilt. The seizures were controlled with phenobarbital, but the dog died 2 days after presentation. Necropsy revealed severe, diffuse, follicular atrophy of the thyroid gland (primary hypothyroidism), severe generalized atherosclerosis, severe pseudolaminar cortical necrosis and acute vasculitis in the cerebrum, and congestive heart failure. The neurologic signs were explained by the pseudolaminar necrosis and associated cerebrovascular atherosclerosis. The cerebrocortical necrosis was believed to be caused by tissue hypoxia secondary to progressive vascular occlusion. Cerebrovascular atherosclerosis, secondary to primary hypothyroidism, was considered the most important cause of the hypoxia.
一只6岁、肥胖、已绝育的雌性杜宾犬因反复癫痫发作1天以及长期周期性共济失调、转圈和头部倾斜病史前来接受临床检查。癫痫发作通过苯巴比妥得到控制，但该犬在就诊后2天死亡。尸检发现甲状腺严重弥漫性滤泡萎缩（原发性甲状腺功能减退）、严重的全身性动脉粥样硬化、大脑严重的假层状皮质坏死和急性血管炎以及充血性心力衰竭。神经症状由假层状坏死和相关的脑血管动脉粥样硬化解释。脑皮质坏死被认为是由进行性血管闭塞继发的组织缺氧引起的。原发性甲状腺功能减退继发的脑血管动脉粥样硬化被认为是缺氧的最重要原因。
