结肠直肠癌患者细胞介导免疫的紊乱。
Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum.
作者信息
Manousos O N, Economidou J, Pathouli C, Merikas G
出版信息
Gut. 1973 Sep;14(9):739-42. doi: 10.1136/gut.14.9.739.
Abstract
The cellular immune mechanisms of patients with adenocarcinoma of colon or rectum were evaluated by studying the lymphocyte response to PHA stimulation. Our results indicate that the serum of cancer patients causes a decreased blastic transformation and H(3) thymidine uptake of the lymphocytes of patients as well as of normal controls. A defect of the lymphocytes unrelated to serum factors was also present in some cancer patients. However, no relationship was found between the degree of transformation and the presence of metastases in the lymph nodes.
摘要
通过研究淋巴细胞对PHA刺激的反应，对结肠癌或直肠癌患者的细胞免疫机制进行了评估。我们的结果表明，癌症患者的血清会导致患者以及正常对照者淋巴细胞的母细胞转化和H(3)胸腺嘧啶核苷摄取减少。一些癌症患者还存在与血清因子无关的淋巴细胞缺陷。然而，未发现转化程度与淋巴结转移情况之间存在关联。
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