Wise P H, Marion M, Pain R W
Br Med J. 1973 Oct 20;4(5885):143-5. doi: 10.1136/bmj.4.5885.143.
In 30 consecutive hyperthyroid patients with diffuse goitre divided dose therapy with carbimazole 40 mg and triiodothyronine 80 mug daily was shown to produce total or subtotal block in thyroid hormonogenesis. Once produced, this block could be invariably maintained with an equivalent single daily dose for periods up to three years. Its notable acceptability to patients, a more stable degree of euthyroid control, ease of assessing suppressibility of trapping, and ability to treat patients in remote areas all support a wider use of this mode of therapy.
在30例连续的弥漫性甲状腺肿甲亢患者中，每日给予40毫克卡比马唑和80微克三碘甲状腺原氨酸的分剂量疗法被证明可导致甲状腺激素生成完全或部分受阻。一旦产生这种阻滞，用等量的每日单一剂量可将其持续维持长达三年。它对患者具有显著的可接受性、甲状腺功能正常控制程度更稳定、易于评估摄取抑制性以及能够治疗偏远地区的患者，所有这些都支持更广泛地使用这种治疗方式。
