Chandler J R
Ann Otol Rhinol Laryngol. 1979 Jul-Aug;88(4 Pt 1):509-14. doi: 10.1177/000348947908800410.
The deleterious effects of ionizing radiation upon the normal tissues of the larynx, even when it is not the specific target of the radiation therapist, are always apparent to the observant and experienced laryngologist. On occasions they are so marked as to obscure the diagnosis of concomitant persistent or recurrent cancer. There is a direct relationship between the number of rads delivered and the severity of the subsequent radiation reaction. A system of classifying such reactions is proposed. Grade 0 is normal. Grades I and II are expected. Grades III and IV may be considered complications and require specific and even energetic treatment. In grade IV reactions, which require operative intervention, laryngectomy may be the treatment of choice.
电离辐射对喉部正常组织的有害影响，即使喉部并非放射治疗师的特定靶器官，对于敏锐且经验丰富的喉科医生来说也总是显而易见的。有时这些影响非常显著，以至于掩盖了同时存在的持续性或复发性癌症的诊断。所给予的拉德剂量与随后放射反应的严重程度之间存在直接关系。本文提出了一种对这类反应进行分类的系统。0级为正常。I级和II级是预期的。III级和IV级可被视为并发症，需要特殊甚至积极的治疗。在需要手术干预的IV级反应中，喉切除术可能是首选的治疗方法。
