Berger G, Freeman J L, Briant T D, Berry M, Noyek A M
J Otolaryngol. 1984 Jun;13(3):160-4.
Radiation has been used to treat carcinoma of the larynx for some 60 years. We have seen some very late complications of radiation to this region. In this paper we present three patients who had radiation-induced necrosis and fibrosis 13, 19, and 22 years after initial treatment. The problem exists of diagnosing and differentiating perichondritis/fibrosis from recurrent carcinoma. However, many times it is impossible to make this distinction clinically, endoscopically, radiologically, or even pathologically. The pathogenesis, clinical features, and treatment of this rare late complication of radionecrosis and/or fibrosis are presented.
放射治疗喉癌已有约60年的历史。我们已经看到了该区域放射治疗的一些非常晚期的并发症。在本文中，我们介绍了三名患者，他们在初次治疗后13年、19年和22年出现了放射性坏死和纤维化。存在诊断和区分软骨膜炎/纤维化与复发性癌的问题。然而，很多时候在临床、内镜、放射学甚至病理学上都无法做出这种区分。本文介绍了这种罕见的放射性坏死和/或纤维化晚期并发症的发病机制、临床特征和治疗方法。
