损伤结缔组织的免疫学研究。针对正常及经链球菌细胞壁损伤的兔皮肤抗血清的血清学和生物学特性。
Immunological studies of injuried connective tissue. Serological and biological properties of antisera to normal and to streptococcal cell wall injured rabbit skin.
作者信息
Jones J M, Schwab J H
出版信息
Immunology. 1973 Oct;25(4):557-66.
Guinea-pigs were immunized with extracts of normal rabbit skin or with extracts of skin lesions induced by intradermal injection of cell walls of group A streptococci. In passive haemagglutination, antisera to lesion extracts were selective for polymorphonuclear leucocyte antigens while antisera to extracts of normal skin reacted equally well with extracts of normal skin and extracts of lesions. Upon intradermal injection into rabbits, antisera to normal skin induced a biphasic intermittent reaction, characterized by mononuclear cell infiltration and persisting for 2–3 weeks. A chronic phase was not seen in rabbits presensitized to guinea-pig serum. Antisera to lesion extracts induced only an acute inflammation which was diminished by 3 days and was gone by 12 days. Reactions were more severe when antisera and streptococcal cell walls were injected into the same site.
用正常兔皮提取物或皮内注射 A 组链球菌细胞壁诱导的皮肤病变提取物对豚鼠进行免疫。在被动血凝试验中，病变提取物的抗血清对多形核白细胞抗原有选择性，而正常皮肤提取物的抗血清与正常皮肤提取物和病变提取物反应同样良好。将正常皮肤的抗血清皮内注射到兔子体内时，会引发双相间歇性反应，其特征为单核细胞浸润，持续 2 - 3 周。对豚鼠血清预先致敏的兔子未出现慢性期。病变提取物的抗血清仅引发急性炎症，3 天后炎症减轻，12 天后炎症消失。当抗血清和链球菌细胞壁注射到同一部位时，反应更严重。
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