Simonson L G, Jackola D
Antimicrob Agents Chemother. 1979 Jul;16(1):9-12. doi: 10.1128/AAC.16.1.9.
A Fusarium dextranase and a Penicillium dextranase were compared for their relative ability to quantitatively reduce the adsorption of (3)H-labeled Steptococcus mutans cells onto hydroxyapatite. Fusarium dextranase-treated hydroxyapatite disks caused a statistically significant decrease in the hydroxyapatite adsorption of both the OMZ 176 and NCTC 10449 strains of S. mutans relative to untreated control disks. The extent of initial bacterial adsorption was not promoted by sucrose-dependent glucan synthesis. Since the Fusarium dextranase has a much greater affinity for hydroxyapatite than the Penicillium dextranase, it could represent an enzyme with improved decay-preventive therapeutic properties. This was concluded because the Fusarium dextranase may interfere with both the initial attachment and later glucan-dependent accumulation of dental plaque microorganisms.
对镰刀菌葡聚糖酶和青霉葡聚糖酶在定量降低³H标记的变形链球菌细胞吸附到羟基磷灰石上的相对能力方面进行了比较。相对于未处理的对照圆盘，经镰刀菌葡聚糖酶处理的羟基磷灰石圆盘使变形链球菌的OMZ 176和NCTC 10449菌株在羟基磷灰石上的吸附量出现了统计学上的显著下降。蔗糖依赖性葡聚糖合成并未促进细菌的初始吸附程度。由于镰刀菌葡聚糖酶对羟基磷灰石的亲和力远高于青霉葡聚糖酶，它可能是一种具有改善的防龋治疗特性的酶。得出这一结论是因为镰刀菌葡聚糖酶可能会干扰牙菌斑微生物的初始附着以及随后的葡聚糖依赖性聚集。
