Jakobiec F A, Shields J A, Desjardins L, Iwamoto T
Arch Ophthalmol. 1979 Sep;97(9):1687-92. doi: 10.1001/archopht.1979.01020020255014.
In spite of the fact that balloon cell change has been recognized ophthalmoscopically and histologically in certain posterior choroidal melanomas, the nature and importance of this observation remain controversial. This article provides a clinicopathologic correlation in two cases of ciliary body melanoma with almost total balloon cell transformation. On the basis of special stains and electron microscopic observations, we have concluded that balloon cells in such cases represent spindle melanoma cells that have undergoing extensive cytoplasmic lipid metamorphosis. The possible mechanisms for this change are considered. Melanomas containing an abundant number of balloon cells are probably comparatively dormant and benign tumors that offer a relatively good prognosis. Although clinical recognition may be difficult, the use of needle biopsy coupled with cytologic diagnosis in selected ciliary body tumors may disclose balloon cell change and help to direct therapy.
尽管在某些脉络膜后黑色素瘤中，通过检眼镜检查和组织学检查已认识到气球样细胞改变，但这一观察结果的性质和重要性仍存在争议。本文提供了两例睫状体黑色素瘤几乎完全发生气球样细胞转化的临床病理相关性。基于特殊染色和电子显微镜观察，我们得出结论，此类病例中的气球样细胞代表经历了广泛细胞质脂质变形的梭形黑色素瘤细胞。我们还考虑了这种变化的可能机制。含有大量气球样细胞的黑色素瘤可能是相对静止的良性肿瘤，预后相对较好。尽管临床识别可能困难，但在选定的睫状体肿瘤中使用针吸活检结合细胞学诊断可能会发现气球样细胞改变，并有助于指导治疗。
