Effects of the comutagens, harman and norharman, on the interaction of a tryptophan pyrolysis product, 3-amino-1-methyl-5H-pyrido (4,3-b) indole with DNA.
作者信息
Lau P P, Luh Y
出版信息
Biochem Biophys Res Commun. 1979 Jul 12;89(1):188-94. doi: 10.1016/0006-291x(79)90962-8.
PMID:475807
Abstract
摘要
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Effects of the comutagens, harman and norharman, on the interaction of a tryptophan pyrolysis product, 3-amino-1-methyl-5H-pyrido (4,3-b) indole with DNA.
Biochem Biophys Res Commun. 1979 Jul 12;89(1):188-94. doi: 10.1016/0006-291x(79)90962-8.
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Activation of a mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole. Identification of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and its reacion with DNA.诱变剂3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚的激活。3-羟基氨基-1-甲基-5H-吡啶并[4,3-b]吲哚的鉴定及其与DNA的反应。
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There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles.几种3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚的DNA亲和力与致突变性之间存在关联。
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Collision-induced dissociation actualized the H+-promoted reaction as observed in vitro; harman formation from beta-carboline-type monoterpenoid glucoindole alkaloids.
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Metabolic activation of 3-amino-5H-pyrido[4,3-b]indole, a highly mutagenic principle in tryptophan pyrolysate, by rat liver enzymes.大鼠肝脏酶对3-氨基-5H-吡啶并[4,3-b]吲哚的代谢激活作用，3-氨基-5H-吡啶并[4,3-b]吲哚是色氨酸热解产物中的一种高致突变成分。
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Metabolic activation of a tryptophan pyrolysis product, 3-amino-1-methyl-5H-pyrido[4,3-b]indole(TRP-P-2) by isolated rat liver nuclei.
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Structural elucidation of a mutagenic metabolite of 3-amino-1-methyl-5H-pyrido[4,3-b]indole.3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚诱变代谢物的结构解析
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