强诱变剂3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚（Trp-P-2）和2-氨基-6-甲基-二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）与核酸的反应。
Reactions of potent mutagens, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) with nucleic acid.
作者信息
Hashimoto Y, Shudo K, Imamura M, Okamoto T
出版信息
Nucleic Acids Symp Ser. 1980(8):s109-12.
Two potent mutagens, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), isolated from a tryptophan pyrolysate, and 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), isolated from a glutamic acid pyrolysate, modified calf thymus DNA in the presence of rat liver microsomes. The major base modified by Trp-P-2 was identified wih 3-(3-guanyl)amino-1-methyl-5H-pyrido[4,3-b]indole. The major base modified by Glu-P-1 was identified with 2-(8-guanyl)amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole. N-acetoxy-Glu-P-1 efficiently modified DNA without microsomes.
从色氨酸热解产物中分离出的两种强诱变剂3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚（Trp-P-2），以及从谷氨酸热解产物中分离出的2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1），在大鼠肝微粒体存在的情况下修饰了小牛胸腺DNA。经鉴定，Trp-P-2修饰的主要碱基为3-(3-鸟嘌呤基)氨基-1-甲基-5H-吡啶并[4,3-b]吲哚。经鉴定，Glu-P-1修饰的主要碱基为2-(8-鸟嘌呤基)氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑。N-乙酰氧基-Glu-P-1在无微粒体的情况下能有效修饰DNA。
Zotero 插件