诱导性高甘油三酯血症期间人体脂肪组织中的脂蛋白脂肪酶活性

Lipoprotein lipase activity in human adipose tissue during induced hypertriglyceridaemia.

作者信息

Holdsworth G, Taylor K G, Galton D J

出版信息

Atherosclerosis. 1979 Jun;33(2):253-8. doi: 10.1016/0021-9150(79)90122-9.

Abstract

Needle biopsies of adipose tissue and blood samples were obtained before and at short intervals after a "bolus" injection of 10% Intralipid. Lipoprotein lipase activities were measured in acetone--ether extracts of the tissue samples. Levels of serum triglyceride began to fall less than 5 min after the injection of the Intralipid with a half-life of 20 min. During this time interval, no significant changes were observed in the activities of lipoprotein lipase in adipose tissue. A patient with a severe hypertriglyceridaemia (Type V) underwent plasma exchange with a reduction in serum triglyceride levels from 11 to 4 mm/l. There was a parallel fall in adipose tissue lipoprotein lipase activity. We conclude that lipoprotein lipase in adipose tissue is unaltered during experimental hypertriglyceridaemia and that the activity of the enzyme in adipose tissue is probably not reduced as a secondary feature of an elevated plasma triglyceride level.

摘要

在静脉快速注射10%英脱利匹特之前及之后的短时间内，获取脂肪组织的针吸活检样本及血样。在组织样本的丙酮 - 乙醚提取物中测量脂蛋白脂肪酶活性。注射英脱利匹特后不到5分钟，血清甘油三酯水平开始下降，半衰期为20分钟。在此时间段内，脂肪组织中脂蛋白脂肪酶的活性未观察到显著变化。一名严重高甘油三酯血症（V型）患者接受了血浆置换，血清甘油三酯水平从11降至4 mmol/L。脂肪组织脂蛋白脂肪酶活性也随之下降。我们得出结论，在实验性高甘油三酯血症期间，脂肪组织中的脂蛋白脂肪酶未发生改变，并且脂肪组织中该酶的活性可能不会作为血浆甘油三酯水平升高的继发特征而降低。