Taylor K G, Galton D J, Holdsworth G
Diabetologia. 1979 May;16(5):313-7. doi: 10.1007/BF01223620.
The activity of lipoprotein lipase (E.C.3.1.1.3.) has been measured in adipose tissue from insulin-independent diabetics with hypertriglyceridaemia, non-diabetics with hypertriglyceridaemia and control patients, all of whom were obese. Although all groups showed an increase of plasma insulin after oral glucose, both the diabetic and nondiabetic hypertriglyceridaemics had impaired activities of lipoprotein lipase in adipose tissue compared to the obese normals (p less than 0.02, p less than 0.03, respectively). A course of insulin therapy (20 u.o.d.) for one week increased the activity of lipoprotein lipase extracted from adipose tissue, lowered plasma triglycerides and improved triglyceride clearance from plasma in a group of diabetics with hypertriglyceridaemia (mean plasma triglyceride 8.7 mmol/l). Our results suggest that a feature in the development of insulin resistance in adult diabetics may be a failure of maintenance of key intracellular enzyme activities involved in lipid metabolism.
在患有高甘油三酯血症的非胰岛素依赖型糖尿病患者、患有高甘油三酯血症的非糖尿病患者以及对照患者（均为肥胖者）的脂肪组织中，已对脂蛋白脂肪酶（E.C.3.1.1.3.）的活性进行了测定。尽管所有组在口服葡萄糖后血浆胰岛素均升高，但与肥胖正常者相比，糖尿病和非糖尿病高甘油三酯血症患者脂肪组织中的脂蛋白脂肪酶活性均受损（分别为p<0.02，p<0.03）。在一组患有高甘油三酯血症（平均血浆甘油三酯8.7 mmol/l）的糖尿病患者中，为期一周的胰岛素治疗疗程（每日20单位）提高了从脂肪组织中提取的脂蛋白脂肪酶的活性，降低了血浆甘油三酯，并改善了甘油三酯从血浆中的清除。我们的结果表明，成年糖尿病患者胰岛素抵抗发展过程中的一个特征可能是维持参与脂质代谢的关键细胞内酶活性失败。
