Kluge R M, Calia F M, McLaughlin J S, Hornick R B
Antimicrob Agents Chemother. 1973 Sep;4(3):270-6. doi: 10.1128/AAC.4.3.270.
Serum concentrations of cephalothin or kanamycin, or both, were determined in 53 patients undergoing cardiopulmonary bypass. Conventional doses of these antibiotics did not provide serum levels above the accepted minimum inhibitory concentrations in children. Adults had adequate serum antibiotic concentrations only when the antimicrobials were administered within 4 h of beginning cardiopulmonary bypass. The impact of these variations upon the occurrence of infectious endocarditis could not be appraised since no cases of infective endocarditis were seen during a 4-month postoperative period.
对53例接受体外循环的患者测定了头孢噻吩或卡那霉素或两者的血清浓度。这些抗生素的常规剂量在儿童中未能使血清水平高于公认的最低抑菌浓度。只有在体外循环开始后4小时内给予抗菌药物时,成人才有足够的血清抗生素浓度。由于在术后4个月期间未发现感染性心内膜炎病例,因此无法评估这些差异对感染性心内膜炎发生的影响。