放线菌素D对肺炎支原体的抑制作用。
Inhibition of Mycoplasma pneumoniae by actinomycin D.
作者信息
Fletcher R D, Jayavasu C, Yoo S, Albertson J N
出版信息
Antimicrob Agents Chemother. 1973 Sep;4(3):376-7. doi: 10.1128/AAC.4.3.376.
Abstract
Growth of Mycoplasma pneumoniae was completely prevented by 0.06 mug of actinomycin D/ml, and 0.00375 mug/ml caused 90% inhibition. It thus appears that M. pneumoniae is more susceptible to actinomycin D than previously reported. Low concentrations (0.019 mug/ml) of the antibiotic primarily inhibited ribonucleic acid synthesis and high concentrations (20 mug/ml) inhibited both ribonucleic and deoxyribonucleic acid synthesis.
摘要
每毫升含0.06微克放线菌素D可完全抑制肺炎支原体生长，每毫升含0.00375微克可产生90%的抑制作用。因此，肺炎支原体似乎比先前报道的对放线菌素D更敏感。低浓度（每毫升0.019微克）的该抗生素主要抑制核糖核酸合成，高浓度（每毫升20微克）则抑制核糖核酸和脱氧核糖核酸合成。
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