食物和片剂剂型对肠溶衣片给药后血浆泼尼松龙水平的影响。
The effect of food and tablet formulation on plasma prednisolone levels following administration of enteric-coated tablets.
作者信息
Lee D A, Taylor G M, Walker J G, James V H
出版信息
Br J Clin Pharmacol. 1979 May;7(5):523-8. doi: 10.1111/j.1365-2125.1979.tb00998.x.
Abstract
1 Plasma prednisolone levels have been compared following the administration of enteric-coated prednisolone to fasted and non-fasted subjects. The effect on plasma levels of altering the formulation of the enteric-coating has also been studied. 2 The presence of food in the stomach at the time of administration does not affect the absorption of enteric-coated prednisolone tablets. 3 There was considerable inter-subject variation in plasma prednisolone levels after administration of shellac based enteric-coated tablets. However, plasma levels were more consistent when a preparation whose formulation was based upon cellulose acetate phthalate (CAP) was given. 4 It is concluded that the pattern of absorption and plasma prednisolone levels depend on the formulation of the enteric coating. The bioavailability of the CAP based preparation is similar to that of plain prednisolone.
摘要
- 已对空腹和非空腹受试者服用肠溶包衣泼尼松龙后血浆泼尼松龙水平进行了比较。还研究了改变肠溶衣制剂对血浆水平的影响。2. 给药时胃内有食物不影响肠溶包衣泼尼松龙片的吸收。3. 服用虫胶基肠溶包衣片后，受试者间血浆泼尼松龙水平存在相当大的差异。然而，给予基于邻苯二甲酸醋酸纤维素（CAP）配方的制剂时，血浆水平更一致。4. 得出的结论是，吸收模式和血浆泼尼松龙水平取决于肠溶衣的配方。基于CAP的制剂的生物利用度与普通泼尼松龙相似。
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