直肠给药的泼尼松龙——主要为局部作用的证据。
Rectally administered prednisolone--evidence for a predominantly local action.
作者信息
Lee D A, Taylor M, James V H, Walker G
出版信息
Gut. 1980 Mar;21(3):215-8. doi: 10.1136/gut.21.3.215.
Abstract
Plasma prednisolone levels have been compared in healthy volunteers and in patients suffering from idiopathic proctocolitis after the administration of standard retention enemata containing either prednisolone-21-phosphate or prednisolone metasulphobenzoate sodium. The levels were significantly lower after the latter, irrespective of the presence or degree of activity of the disease. Prednisolone metasulphobenzoate appeared to be as effective as the 21-phosphate ester for the treatment of proctocolitis in the few patients where the two drugs were compared. It seems possible that the beneficial effect of the form of therapy is exerted predominantly locally, rather than by systemic action.
摘要
对健康志愿者以及患有特发性直肠结肠炎的患者，在给予含有磷酸泼尼松龙或甲磺苯甲酸钠泼尼松龙的标准保留灌肠剂后，比较了血浆泼尼松龙水平。无论疾病是否存在或活动程度如何，使用后者后血浆泼尼松龙水平显著较低。在少数比较了这两种药物的患者中，甲磺苯甲酸钠泼尼松龙治疗直肠结肠炎的效果似乎与21 - 磷酸酯一样有效。治疗形式的有益作用似乎主要是在局部发挥，而非通过全身作用。
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