Triger D R, Wright R
Immunology. 1973 Dec;25(6):951-6.
Using the previously described animal model in which the effect of hepatic uptake of SRBC injected into the rat portal venous system was studied, the effect of two hepatotoxins—carbon tetrachloride and D-galactosamine—is described. Carbon tetrachloride results in an enhanced primary immune response to SRBC injection and the abolition of the difference in immune response to repeated injections via the portal vein and inferior vena cava. Radioactive labelling of SRBC shows that the enhanced primary response is accompanied by a significant reduction of hepatic uptake. No significant increase in splenic uptake was noted. In contrast, the production of galactosamine hepatitis did not affect the immune response to SRBC. These findings are considered in the light of the pathogenesis of the hyperglobulinaemia which is associated with liver disease.
利用先前描述的动物模型（该模型用于研究注入大鼠门静脉系统的绵羊红细胞（SRBC）的肝摄取效应），描述了两种肝毒素——四氯化碳和D-半乳糖胺的效应。四氯化碳导致对注射SRBC的初次免疫反应增强，并且消除了经门静脉和下腔静脉重复注射时免疫反应的差异。SRBC的放射性标记显示，增强的初次反应伴随着肝摄取的显著减少。未观察到脾摄取有显著增加。相比之下，半乳糖胺性肝炎的发生并未影响对SRBC的免疫反应。根据与肝病相关的高球蛋白血症的发病机制对这些发现进行了考量。
